Pathophysiology of Guillian-Barré Syndrome (GBS) Essay

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Guillian-Barré Syndrome (GBS) derives from a disorder associated with a Campylobacter jejuni infection. Campylobacter is known with multiple pathologic forms of GBS, including the demyelinating and axonal forms. GBS can cause weakness in the limbs and an absence of reflexes. There is a weakness in proximal and distal, and often, respiratory cases are involved. GBS can lead to paralysis, depending on the virulence. If virulent enough, GBS will affect the respiratory system, which often leads to patients in ventilating machines due to difficulty in breathing.
There are six subtypes to GBS with acute inflammatory demyelinating polyneuropathy being the most common form. The immune system attacks the Schwan cell membranes in response to a
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Recovery usually is between one and three months.
Acute motor axonal neuropathy (AMAN) is characterized for its paralytic nature. This form of GBS pathologically has variable motor nerve fiber degeneration. It varies from severity and the moderate of sensory fibers. There is little lymphocytic inflammation and like most cases, it is a forerunner for an infection caused by Campylobacter jejuni. AMAN is a new disorder that is caused by anti-bodies and complement-mediated attack on the membrane surrounding the axon of motor fibers.
Acute motor sensory axonal neuropathy (AMSAN) is has equal features like AMAN with its paralytic nature but affects the sensory nerves with harshness. Findings include severe axonal degeneration of motor and sensory nerve fibers. The main characteristic of AMSAN is muscle wasting because of the pathological findings of massive damage to nerve fibers. Another characteristic of AMSAN is the acute, continuing of distal weakness. Compared to AMAN, recovery is poorer. AMSAN is associated with former Campylobacter jejuni.
Acute panautomonic neuropathy is the rarest form of GBS. There is a severe damage of the sympathetic and parasympathetic function of the nervous system. There is a specific loss of small myelinated and unmyelinated nerve fibers. Most patients experience grave postural hypotension, bowel and bladder withhold, reduction of

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