Pathophysiology of Guillian-Barré Syndrome (GBS) Essay
There are six subtypes to GBS with acute inflammatory demyelinating polyneuropathy being the most common form. The immune system attacks the Schwan cell membranes in response to a …show more content…
Acute motor axonal neuropathy (AMAN) is characterized for its paralytic nature. This form of GBS pathologically has variable motor nerve fiber degeneration. It varies from severity and the moderate of sensory fibers. There is little lymphocytic inflammation and like most cases, it is a forerunner for an infection caused by Campylobacter jejuni. AMAN is a new disorder that is caused by anti-bodies and complement-mediated attack on the membrane surrounding the axon of motor fibers.
Acute motor sensory axonal neuropathy (AMSAN) is has equal features like AMAN with its paralytic nature but affects the sensory nerves with harshness. Findings include severe axonal degeneration of motor and sensory nerve fibers. The main characteristic of AMSAN is muscle wasting because of the pathological findings of massive damage to nerve fibers. Another characteristic of AMSAN is the acute, continuing of distal weakness. Compared to AMAN, recovery is poorer. AMSAN is associated with former Campylobacter jejuni.
Acute panautomonic neuropathy is the rarest form of GBS. There is a severe damage of the sympathetic and parasympathetic function of the nervous system. There is a specific loss of small myelinated and unmyelinated nerve fibers. Most patients experience grave postural hypotension, bowel and bladder withhold, reduction of